MersV1, Main, Exploration, bibRecord, 004D32

Xrep, a plasmid-stimulating X chromosomal sequence bearing similarities to the BK virus replication origin and viral enhancers

Identifieur interne : 004D32 ( Main/Exploration ); précédent : 004D31; suivant : 004D33

Xrep, a plasmid-stimulating X chromosomal sequence bearing similarities to the BK virus replication origin and viral enhancers

Auteurs : Donald E. Riley [États-Unis] ; Raymond Reeves [États-Unis] ; Stanley M. Gartler [États-Unis]

Source :

Nucleic Acids Research [ 0305-1048 ] ; 1986.

RBID : ISTEX:EE4D6E535819A9836276529C1DA809945DF93F21

Descripteurs français

English descriptors

KwdEn :
- Acetyltransferases (genetics), BK Virus (genetics), Base Sequence, Chloramphenicol O-Acetyltransferase, Chromosome Deletion, Chromosome Mapping, Cloning, Molecular, DNA, Viral (analysis), Enhancer Elements, Genetic, Escherichia coli (genetics), Genes, Regulator, Humans, Plasmids, Polyomavirus (genetics), Saccharomyces cerevisiae (genetics), Sequence Homology, Nucleic Acid, Virus Replication, X Chromosome.
MESH :
- chemical , analysis : DNA, Viral.
- chemical , genetics : Acetyltransferases.
- genetics : BK Virus, Escherichia coli, Polyomavirus, Saccharomyces cerevisiae.
- Base Sequence, Chloramphenicol O-Acetyltransferase, Chromosome Deletion, Chromosome Mapping, Cloning, Molecular, Enhancer Elements, Genetic, Genes, Regulator, Humans, Plasmids, Sequence Homology, Nucleic Acid, Virus Replication, X Chromosome.

Abstract

The human X chromosome-linked fragment, “Xrep, ” was sequenced because it exerts a positive effect on plasmid growth in both E. coli and Saccharomyces cerevisiae. The sequence revealed three features similar to the human BK virus replication origin: (1) Xrep has a true palindrome, CCTCC(T)3CCTCC, which is similar to “true” palindrome-like sequences found at the replication origins of polyoma [CCTC(T/C)10CTCC], BK [CCTC(A/G)8CCTCC] and SV40 [CCTCC(A)6GCCTCC] viruses. (2) Twenty nucleotides away from the true palindrome, Xrep has the sequence GAATCCTATTCACTTTT while BK virus, the human analogue of SV40, has GAAATCCCTATTCTTTT in exactly the same position relative to the true palindrome. These two 17-mers differ only in the positions of two nucleotides comparing Xrep and BK virus. (3) Also similar to the replication origins of DNA viruses, Xrep appears to have a cluster of enhancers adjacent to the origin-like sequences. Potent enhancer-like activity was detected in pSVl CAT/Xrep constructs. Xrep may originate from an endogenous virus, or from an X chromosomal replication origin.

Url:

https://api.istex.fr/ark:/67375/HXZ-1CZ8STPF-9/fulltext.pdf

DOI: 10.1093/nar/14.23.9407

Affiliations:

Le document en format XML

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<term>Chromosome Deletion</term>
<term>Chromosome Mapping</term>
<term>Cloning, Molecular</term>
<term>DNA, Viral (analysis)</term>
<term>Enhancer Elements, Genetic</term>
<term>Escherichia coli (genetics)</term>
<term>Genes, Regulator</term>
<term>Humans</term>
<term>Plasmids</term>
<term>Polyomavirus (genetics)</term>
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<term>Sequence Homology, Nucleic Acid</term>
<term>Virus Replication</term>
<term>X Chromosome</term>
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<term>Chloramphenicol O-acetyltransferase</term>
<term>Chromosome X</term>
<term>Clonage moléculaire</term>
<term>Délétion de segment de chromosome</term>
<term>Escherichia coli (génétique)</term>
<term>Gènes régulateurs</term>
<term>Humains</term>
<term>Plasmides</term>
<term>Polyomavirus (génétique)</term>
<term>Réplication virale</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence nucléotidique</term>
<term>Virus BK (génétique)</term>
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<front><div type="abstract">The human X chromosome-linked fragment, “Xrep, ” was sequenced because it exerts a positive effect on plasmid growth in both E. coli and Saccharomyces cerevisiae. The sequence revealed three features similar to the human BK virus replication origin: (1) Xrep has a true palindrome, CCTCC(T)3CCTCC, which is similar to “true” palindrome-like sequences found at the replication origins of polyoma [CCTC(T/C)10CTCC], BK [CCTC(A/G)8CCTCC] and SV40 [CCTCC(A)6GCCTCC] viruses. (2) Twenty nucleotides away from the true palindrome, Xrep has the sequence GAATCCTATTCACTTTT while BK virus, the human analogue of SV40, has GAAATCCCTATTCTTTT in exactly the same position relative to the true palindrome. These two 17-mers differ only in the positions of two nucleotides comparing Xrep and BK virus. (3) Also similar to the replication origins of DNA viruses, Xrep appears to have a cluster of enhancers adjacent to the origin-like sequences. Potent enhancer-like activity was detected in pSVl CAT/Xrep constructs. Xrep may originate from an endogenous virus, or from an X chromosomal replication origin.</div>
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Xrep, a plasmid-stimulating X chromosomal sequence bearing similarities to the BK virus replication origin and viral enhancers

Xrep, a plasmid-stimulating X chromosomal sequence bearing similarities to the BK virus replication origin and viral enhancers

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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